吉西他滨一磷酸（Gemcitabine 5'-phosphate）是吉西他滨的活性中间体之一。吉西他滨一磷酸盐显示出协同抗癌作用。
货号:ajcx22558
CAS:116371-67-6,1638288-31-9
分子式:C9H12F2N3O7P
分子量：343.2
溶解度:DMF: 10 mg/ml,DMSO: 10 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Gemcitabine monophosphate is a monophosphate form of the deoxycytidine analog gemcitabine .¹It has synergistic effects when used in nanoparticle form in combination with cisplatin nanoparticlesin vitroat a one-to-one molar ratio (IC₅₀s = 5.95 and 34.8 for the nanoparticle combination and gemcitabine monophosphate alone, respectively). In a stroma-rich mouse xenograft model, the nanoparticle combination of gemcitabine and cisplatin inhibits tumor growth and increases apoptosis.

1.Zhang, J., Miao, L., Guo, S., et al.Synergistic anti-tumor effects of combined gemcitabine and cisplatin nanoparticles in a stroma-rich bladder carcinoma modelJ. Control. Release18290-96(2014)