An internal standard for the quantification of guanfacine
货号:ajcx22596
CAS:1189924-28-4
分子式:C8[13C]H9Cl2[15N]3O
分子量：250.1
溶解度:Methanol: slightly, sonicated
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Guanfacine-¹³C,¹⁵N₃is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an α₂-adrenergic receptor (α₂-AR) agonist with K_ivalues of 93, 1,380, and 3,890 nM for α_2A-, α_2B-, and α_2C-ARs, respectively, in a radioligand binding assay.¹It has EC₅₀values of 52, 288, and 602 nM for α_2A-, α_2B-, and α_2C-ARs, respectively, for stimulated [³⁵S]GTPγS binding. It also binds to imidazoline receptor 1 (K_i= 19 nM in a radioligand binding assay).²Guanfacine (0.3-5 mg/kg) binds to adrenergic receptors in the central nervous system and lowers blood pressure in hypertensive rats in a dose-dependent manner.³It also improves spatial working memory deficits induced by hypobaric hypoxia in rats.⁴Formulations containing guanfacine are used in the treatment of high blood pressure and attention deficit hyperactivity disorder (ADHD).

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