RS 127445 hydrochloride 是一种选择性、高亲和力、口服生物可利用的 5-HT2B 受体拮抗剂，pKi 为 9.5。
货号:ajcx26798
CAS:199864-86-3
分子式:C17H16FN3.HCl
分子量：317.79
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

High affinity 5-HT2B receptor antagonist (pKi = 9.5). Displays 1000-fold selectivity for 5-HT2B with good bioavailability.

Bonhaus et al (1999) RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist. Br.J.Pharmacol. 127 1075 PMID:10455251 |Callebert et al (2006) Evidence for a control of plasma serotonin levels by 5-Hydroxytryptamine2B receptors in mice. J.Pharmacol.Exp.Ther. 317 724 PMID:16461587