USP7-IN-8 (example 81) 是一种选择性的泛素特异性蛋白酶 7 (USP7) 抑制剂，在 Ub-Rho110 分析中的 IC50 为 1.4 μM。USP7-IN-8 对 USP47 和 USP5 没有活性。USP7-IN-8 具有抗癌作用。
货号:ajcx33602
CAS:2009273-60-1
分子式:C21H21N3O2
分子量：347.41
溶解度:DMSO : 83.33 mg/mL (239.86 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

USP7-IN-8 (example 81) is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM in an Ub-Rho110 assay. USP7-IN-8 shows no activity against USP47 and USP5. USP7-IN-8 has anticancer effects[1].

USP7 or HAUSP (herpesvirus-associated USP) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. USP7 is a eubiquitinase (DUB) that controls cell proliferation by altering the stability of Mdm2, p53, PTEN and FOXO4[1].

[1]. Robert Blake, et al. Usp7 inhibitor compounds and methods of use. US20160272588A1.