IYPTNGYTR acetate，一种脱酰胺敏感的特征肽，是曲妥珠单抗 (Trastuzumab) 的脱酰胺产物。 IYPTNGYTR acetate 可用于监测体内曲妥珠单抗的代谢。
货号:ajcx34880
CAS:N/A
分子式:C51H77N13O17
分子量：1144.23
溶解度:H2O : 125 mg/mL (109.24 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

IYPTNGYTR acetate, a deamidation-sensitive signature peptide, is a deamidation product of Trastuzumab. IYPTNGYTR acetate can be used to monitor in vivo Trastuzumab metabolism[1].

IYPTNGYTR is deamidated at pH 7.5 and above, with a higher deamidation rate when the pH increases[1].

[1]. Bults P, et, al. LC-MS/MS-Based Monitoring of In Vivo Protein Biotransformation: Quantitative Determination of Trastuzumab and Its Deamidation Products in Human Plasma. Anal Chem. 2016 Feb 2;88(3):1871-7.