| 规格: | 98% |
| 分子量: | 479.6 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
Background:
Fumitremorgin B is a mycotoxin originally isolated fromA. fumigatus.1,2It induces tremors in and is lethal to mice (LD50= 5.4 mg/kg, i.v.). It is also toxic to brine shrimp (LC50= 13.6 μg/ml).3Fumitremorgin B is active against the phytopathogenic fungiB. cinerea,A. solani,A. alternata,C. gloeosporioides,F. solani,F. oxysporum, andG. saubinettii(MICs = 6.25-100 μg/ml). It has antifeedant activity against armyworm (M. separata) larvae when applied to fresh wheat leaves. Fumitremorgin B inhibits the proliferation of U937 and PC3 cells (IC50s = 14.12 and 43.36 μM, respectively).4
1.Yamazaki, M., Suzuki, S., and Miyaki, K.Tremorgenic toxins from Aspergillus fumigatus FresChem. Pharm. Bull. (Tokyo)19(8)1739-1740(1971) 2.Yamazaki, M., and Suzuki, S.Toxicology of tremorgenic mycotoxins, fumitremorgin A and BDev. Toxicol. Environ. Sci.12273-282(1986) 3.Li, X.-J., Zhang, Q., Zhang, A.-L., et al.Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activitiesJ. Agric. Food Chem.60(13)3424-3431(2012) 4.Wang, Y., Li, Z.-L., Bai, J., et al.2,5-diketopiperazines from the marine-derived fungus Aspergillus fumigatus YK-7Chem. Biodivers.9(2)85-93(2012)
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