(Rac)-Benpyrine 是 Benpyrine 的消旋体，是一种有效的口服活性 TNF-α 抑制剂。
货号:ajcx11566
CAS:1333714-43-4
分子式:C??H??N?O
分子量：308.34
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(Rac)-Benpyrine, a racemate of Benpyrine, is a potent and orally active TNF-α inhibitor. (Rac)-Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1].

(Rac)-Benpyrine (Compound 001; 5-10 μM; 24 hours) treatment inhibits the expression level of TNF-α downstream pathway protein NF-κB in the nucleus in RAW264.7 macrophages[1].

(Rac)-Benpyrine (Compound 001; 25-50 mg/kg; oral gavage; daily; for 3 weeks; Kunming mice) treatment obviously reduces the inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum, and the anti-inflammatory factor IL-10 is obviously increased, the foot swelling degree of the arthritis part is also obviously slowed down, and the weight index increase caused by the arthritis also has no obvious reduction[1].
参考文献:

[1]. Hua Li, et al. Compound with TNF- α inhibitory activity and application. CN111320630A.