A neuropeptide with diverse biological activities
货号:ajcx22178
CAS:N/A
分子式:C4H4D8N2S2.2HCl
分子量：233.3
溶解度:DMSO: 5 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Cystamine-d₈(hydrochloride) is intended for use as an internal standard for the quantification of cystamine by GC- or LC-MS. Cystamine is an organic disulfide that inhibits tissue transglutaminase (TGM2) with an IC₅₀value of approximately 2.5 mM.¹It is orally available and is neuroprotective in mouse models of Huntington's disease.^2,3Cystamine also inhibits caspase-3, increases intracellular glutathione, and reduces inflammation in a rat model of inflammatory bowel disease.⁴

1.Smethurst, P.A., and Griffin, M.Measurement of tissue transglutaminase activity in a permeabilized cell system: Its regulation by Ca2+ and nucleotidesBiochem. J.313(pt 3)803-808(1996) 2.Dedeoglou, A., Kubilus, J.K., Jeitner, T.M., et al.Therapeutic effects of cystamine in a murine model of Huntington's diseaseJ. Neurosci.22(20)8942-8950(2002) 3.Borrell-PagÈs, M., Canals, K.P., CordeliÈrs, F.P., et al.Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminaseJ. Clin. Invest.116(5)1410-1424(2006) 4.Elli, L., Ciulla, M.M., Busca, G., et al.Beneficial effects of treatment with transglutaminase inhibitor cystamine on the severity of inflammation in a rat model of inflammatory bowel diseaseLab. Invest.91(3)452-461(2011)