A desulfated peptide fragment of hirudin
货号:ajcx25160
CAS:N/A
分子式:C66H93N13O25·XCF3COOH
分子量：1468.5
溶解度:DMF: 1 mg/ml,DMSO: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Hirudin (54-65; non-sulfated) is a desulfated peptide fragment of hirudin, an anticoagulant produced byH. medicinalis.¹It inhibits fibrin clot formation induced by isolated bovine thrombin with an IC₅₀value of 3.7 µM.²

1.Niehrs, C., Huttner, W.B., Carvallo, D., et al.Conversion of recombinant hirudin to the natural form by in vitro tyrosine sulfation. Differential substrate specificities of leech and bovine tyrosylprotein sulfotransferasesJ. Biol. Chem.265(16)9314-9318(1990) 2.Payne, M.H., Krstenansky, J.L., Yates, M.T., et al.Positional effects of sulfation in hirudin and hirudin PA related anticoagulant peptidesJ. Med. Chem.34(3)1184-1187(1991)