| 规格: | 98% |
| 分子量: | 293.27 |
| 包装 | 价格(元) |
| 500ug | 电议 |
| 1mg | 电议 |
Background:
MitoBloCK-10 (MB-10) is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity. MitoBloCK-10 (MB-10) inhibits Tim44 (C-terminal domain) binding to the precursor and to Hsp70[1].
MB-10 (100 μM) is a potential attenuator of protein import into mitochondria[1].MB-10 inhibits the import of substrates that use the TIM23 import pathway[1].MB-10 (0-100 μM) inhibits protein import into mammalian mitochondria[1]. Cell Viability Assay[1] Cell Line: A plasmid expressing Su9-Ura3-myc was integrated at the LEU2 locus in WT and tim23-2 strains.
[1]. Non Miyata, et al. Adaptation of a Genetic Screen Reveals an Inhibitor for Mitochondrial Protein Import Component Tim44. J Biol Chem. 2017 Mar 31;292(13):5429-5442.
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