Belvarafenib (TFA) 是一种有效的，广泛的迅速加速纤维肉瘤激酶 (RAF) 的抑制剂，其对 B-RAF，B-RAFv600E 和C-RAF 的 IC50 值分别为 56 nM, 7 nM 和 5 nM。
货号:ajcx13752
CAS:N/A
分子式:C25H17ClF4N6O3S
分子量：592.95
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Belvarafenib (TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively[1]. IC50: 56 nM(B-RAF), 7 nM(B-RAFv600E), 5 nM(C-RAF)[1].

Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC50s of 10 nM, 23 nM and 44 nM, respectively[1].

[1]. WO 2013/100632 A1.