Rhein sodium (also known as Monorhein; NSC 38629 sodium) is a naturally occuring anthraquinone compound isolated from the fresh rhizome of Rheum coreanum Nakai, which shows anti-inflammation and antitumor activities. Rhein at 35 μM can effectively inhibit the synthesis of IL-1β on human osteoarthritis synovium, as well as the action of this cytokine at the cartilage level, by reducing the number of chondrocyte IL-1R and inhibiting IL-1β induced NO production in chondrocytes and cartilage. Rhein also induces apoptosis in human promyelocytic leukemia cells (HL-60), characterized by caspase activation, poly(ADP)ribose polymerase (PARP) cleavage, and DNA fragmentation.

纯度：≥98%