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Empagliflozin-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Empagliflozin-d4图片
规格:98%
分子量:454.9
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx22410
CAS:N/A
分子式:C23H23D4ClO7
分子量:454.9
溶解度:DMSO: Solube
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Empagliflozin-d4contains four deuterium atoms and is intended for use as an internal standard for the quantification of empagliflozin by GC- or LC-MS. Empagliflozin is a potent SGLT2 inhibitor (IC50= 3.1 nM) that demonstrates a high degree of selectivity (>2,500-fold) over SGLT1, 4, 5, and 6.1In clinical trials of patients with type 2 diabetes, formulations containing empagliflozin lowered fasting and postprandial glucose levels by increasing total glucose excretion, improving β-cell function, and shifting substrate utilization from glucose to lipids.2


1.Grempler, R., Thomas, L., Eckhardt, M., et al.Empagliflozin, a novel selective sodium glucose contransporter-2 (SGLT-2) inhibitor: Characterisation and comparison with other SGLT-2 inhibitorsDiabetes Obes. Metab.14(1)83-90(2012) 2.Ndefo, U.A., Anidiobi, N.O., Basheer, E., et al.Empagliflozin (Jardiance): A novel SGLT2 inhibitor for the treatment of type-2 diabetesP.T.40(6)364-368(2015)