Stafib-1 是首个选择性的 STAT5b SH2 结构域的抑制剂，其 Ki 值为 44 nM，IC50 值为 154 nM。
货号:ajcx33358
CAS:1688703-26-5
分子式:C26H24N2O11P2
分子量：602.42
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Stafib-1 is the first selective inhibitor of the STAT5b SH2 domain, with a Ki of 44 nM and an IC50 of 154 nM[1].

Stafib-1 is the first small molecule which inhibits the STAT5b SH2 domain with more than 50-fold selectivity over STAT5a[1].

[1]. Nagarajan Elumalai, et al. Rational development of Stafib-2: a selective, nanomolar inhibitor of the transcription factor STAT5b. Sci Rep. 2017 Apr 11;7(1):819.