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1,2,3,4-Tetrahydrostaurosporine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
1,2,3,4-Tetrahydrostaurosporine图片
包装:1mg
规格:98%
市场价:6890元
分子量:470.6

产品介绍
A mutant EGFR inhibitor
货号:ajcx20436
CAS:220038-19-7
分子式:C28H30N4O3
分子量:470.6
溶解度:Acetone: slightly soluble,DMSO: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

1,2,3,4-Tetrahydrostaurosporine is a derivative of staurosporine and an inhibitor of mutant EGFR (IC50 = 74 nM for EGFRT790M).1 It is selective for EGFRT790M over wild-type EGFR (IC50 = 390 nM). It also binds to Janus kinase 3 (JAK3).2


|1. Song, X., Liu, X., and Ding, X. Staurosporine scaffold-based rational discovery of the wild-type sparing reversible inhibitors of EGFR T790M gatekeeper mutant in lung cancer with analog-sensitive kinase technology. J. Mol. Recognit. 30(4), (2017).|2. Boggon, T.J., Li, Y., Manley, P.W., et al. Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog. Blood 106(3), 996-1002 (2005).