An internal standard for the quantification of thymidine
货号:ajcx26004
CAS:347841-67-2
分子式:C10H10D4N2O5
分子量：246.3
溶解度:DMF: 16 mg/mL,DMSO: 10mg/mL,PBS (pH 7.2): 5mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Thymidine-d₄is intended for use as an internal standard for the quantification of thymidine by GC- or LC-MS. Thymidine is a pyrimidine nucleoside composed of a deoxyribose sugar and thymine base.¹It is phosphorylated by thymidine kinase 2 (TK2) in mitochondria to form deoxythymidine monophosphate .²Oral administration of thymidine in combination with deoxycytidine increases lifespan in aTk2 H126Nknock-in mouse model of TK2 deficiency.

1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Biochemistry(2002) 2.Lopez-Gomez, C., Levy, R.J., Sanchez-Quintero, M.J., et al.Deoxycytidine and deoxythymidine treatment for thymidine kinase 2 deficiencyAnn. Neurol.81(5)641-652(2017)