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Aegeline
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Aegeline图片
包装:500mg
规格:98%
市场价:445元
分子量:297.35

产品介绍
Aegeline是一种主要生物碱,模拟酵母SNARE蛋白Sec22p抑制酵母α-突触核蛋白和Bax毒性。Aegeline恢复αsyn或Bax抑制的酵母细胞生长。
货号:ajcx30128
CAS:456-12-2
分子式:C18H19NO3
分子量:297.35
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity[1].

Aegeline also prevents growth block in cells expressing the more toxic A53T α-synuclein mutant. Restoration of cell growth occurred through inhibition of increased ROS levels, mitochondrial membrane potential loss and nuclear DNA fragmentation, characteristics of apoptosis manifested in α-synuclein orBax-expressing cells[1].Aegeline shows weak inhibitory effects on the histamine release from RPMCs, even though still succeed to inhibit when the histamine release induced by thapsigargin[2].


[1]. Derf A, et al. a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast [published correction appears in Bioorg Med Chem Lett. 2019 Aug 15;29(16):2437-2438]. Bioorg Med Chem Lett. 2019;29(3):454‐460. [2]. Nugroho AE, et al. Effects of aegeline, a main alkaloid of Aegle Marmelos Correa leaves, on the histamine release from mast cells. Pak J Pharm Sci. 2011;24(3):359‐367.