MAGL inhibitor compound 23 is an inhibitor of monoacylglycerol lipase (MAGL; IC50 = 80 nM).
货号:ajcx17672
CAS:2324160-91-8
分子式:C22H24FNO3
分子量：369.4
溶解度:DMF: 25 mg/ml,DMF:PBS (pH 7.2) (1:6): 0.14 mg/ml,DMSO: 20 mg/ml,Ethanol: 2.5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MAGL inhibitor compound 23 is an inhibitor of monoacylglycerol lipase (MAGL; IC50 = 80 nM). It is selective for MAGL over cannabinoid receptor 1 (CB1), CB2, fatty acid amide hydrolase (FAAH), α/β-hydrolase domain-containing protein 6 (ABHD6), and ABHD12 (IC50s = >10 μM). MAGL inhibitor compound 23 inhibits the growth of HCT116, MDA-MB-231, Caov-3, OVCAR-3, and SKOV3 cells (IC50s = 21, 7.9, 25, 57, and 15 μM, respectively) but not MRC5 cells (IC50 = >100 μM). It increases the levels of 2-arachidonoyl glycerol in mouse brain and plasma when administered at a dose of 50 mg/kg.