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Apigenin 7-O-Glucuronide(hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Apigenin 7-O-Glucuronide(hydrate)图片
规格:98%
分子量:446.4
包装与价格:
包装价格(元)
1mg电议
10mg电议
5mg电议

产品介绍
C21H18O11•XH2O
货号:ajcx24184
CAS:N/A
分子式:C21H18O11•XH2O
分子量:446.4
溶解度:DMF: 10 mg/ml,DMSO: 10 mg/ml,PBS (pH 7.2): 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Apigenin 7-O-glucuronide is a flavonoid that has been found inJ. sigillataand has diverse biological activities.1,2,3,4It inhibits matrix metalloproteinase-3 (MMP-3), MMP-8, MMP-9, and MMP-13 (IC50s = 12.87, 22.39, 17.52, and 0.27 μM, respectively).1,2,3,4Apigenin 7-O-glucuronide also inhibits protein tyrosine phosphatase 1B (PTP1B), acetylcholinesterase (AChE), and aldose reductase with IC50values of 7.14, 62.96, and 107.1 µM, respectively.2,3It inhibits LPS-induced production of nitric oxide, prostaglandin E2, and TNF-α in RAW 264.7 cells when used at a concentration of 100 µM.4Apigenin 7-O-glucuronide (5 or 10 mg/kg) improves survival in a mouse model of septic shock induced by LPS.


1.Crasci, L., Basile, L., Panico, A., et al.Correlating in vitro target-oriented screening and docking: Inhibition of matrix metalloproteinases activities by flavonoidsPlanta Med.83(11)901-911(2017) 2.Nguyen, D.H., Seo, U.M., Zhao, B.T., et al.Ellagitannin and flavonoid constituents from Agrimonia pilosa ledeb. with their protein tyrosine phosphatase and acetylcholinesterase inhibitory activitiesBioorg. Chem.72293-300(2017) 3.Yoo, N.H., Jang, D.S., Yoo, J.L., et al.Erigeroflavanone, a flavanone derivative from the flowers of Erigeron annuus with protein glycation and aldose reductase inhibitory activityJ. Nat. Prod.71(4)713-715(2008) 4.Hu, W., Wang, X., Wu, L., et al.Apigenin-7-O-β-D-glucuronide inhibits LPS-induced inflammation through the inactivation of AP-1 and MAPK signaling pathways in RAW 264.7 macrophages and protects mice against endotoxin shockFood Funct.7(2)1002-1013(2016)