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9-Methoxyellipticine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
9-Methoxyellipticine图片
规格:98%
分子量:276.3
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
An alkaloid with anticancer activity
货号:ajcx24694
CAS:10371-86-5
分子式:C18H16N2O
分子量:276.3
溶解度:
纯度:98%
存储:Store at -20°C
库存:现货

Background:

9-Methoxyellipticine is an alkaloid and a derivative of the DNA intercalating agent ellipticine that has been found inO. maculataand has anticancer activity.1,2It intercalates into DNA and is an inhibitor of wild-type c-Kit and c-Kit containing the D816V activating mutation (c-KitD816V; IC50s = 0.8 and 0.6 µM, respectively).2,39-Methoxyellipticine inhibits proliferation of Ba/F3 cells in the presence of the c-Kit ligand SCF and Ba/F3 cells expressing c-KitD816V(IC50s = 0.5 and 0.3 µM, respectively).2It also increases survival in a variety of rodent tumor models.1


1.Svoboda, G.H., Poore, G.A., and Montfort, M.L.Alkaloids of Ochrosia maculata Jacq. (Ochrosia borbonica Gmel.). Isolation of the alkaloids and study of the antitumor properties of 9-methoxyellipticineJ. Pharm. Sci.57(10)1720-1725(1968) 2.VendÔme, J., Letard, S., Martin, F., et al.Molecular modeling of wild-type and D816V c-Kit inhibition based on ATP-competitive binding of ellipticine derivatives to tyrosine kinasesJ. Med. Chem.48(20)6194-6201(2005) 3.Festy, B., Poisson, J., and Paoletti, C.A new DNA intercalating drug: Methoxy-9-ellipticineFEBS Lett.17(2)321-323(1971)