Mocravimod hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

规格:	98%
分子量:	480.45

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议

产品介绍

Mocravimod hydrochloride (KRP-203) 是一种免疫抑制剂，有效的，具有口服活性的 S1PR1 (1-磷酸鞘氨醇受体 1 型) 激动剂。
货号:ajcx33502
CAS:509088-69-1
分子式:C24H27Cl2NO3S
分子量：480.45
溶解度:DMSO : 100 mg/mL (208.14 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Mocravimod hydrochloride (KRP-203), an immunosuppressant, is a potent and orally active S1PR1 (sphingosine 1-phosphate receptor type 1) agonist[1][2].

Mocravimod hydrochloride (KRP-203) ameliorates atherosclerosis in LDL-R-/- Mice[1]. Mocravimod hydrochloride (KRP-203) (orally; 0.1 and 1 mg/kg/day; for 100 days) prolongs graft survival and attenuates chronic rejection in mHC-disparate rat heart allografts[2].

[1]. PotÌ F, et al. KRP-203, sphingosine 1-phosphate receptor type 1 agonist, ameliorates atherosclerosis in LDL-R-/- mice. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1505-12.
[2]. Shimizu H, et al. KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronicrejection in rat skin and heart allografts. Circulation. 2005 Jan 18;111(2):222-9. Epub 2005 Jan 10.