AC 186 是一种选择性非甾体雌激素受体 β (ERβ) 激动剂，对 ERβ 和 ERα 的 EC50 分别为 6 nM 和 5000 nM。
货号:ajcx26906
CAS:1421854-16-1
分子式:C18H17F3O
分子量：306.32
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent and selective ERβ agonist (EC50 values are 6 and 5000 nM for ERβ and ERα respectively). Exhibits gender selective neuroprotective effects in a male rat model of Parkinson's disease. Decreases Aβ levels in combination with ACP-105 in a rat model of Alzheimer's disease.

George et al (2013) Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease. ACS Chem.Neurosci. 4 1537 PMID:24020966 |McFarland et al (2013) AC-186, a selective nonsteroidal estrogen receptor β agonist, shows gender specific neuroprotection in a Parkinson's disease rat model. ACS Chem.Neurosci. 4 1249 PMID:23898966