An internal standard for the quantification of stearoyl-L-carnitine
货号:ajcx23530
CAS:2245711-27-5
分子式:C25H47D3NO4.Cl
分子量：467.1
溶解度:DMF: 20 mg/ml,DMSO: 14 mg/ml,Ethanol: 20 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Stearoyl-L-carnitine-d₃(chloride) is intended for use as an internal standard for the quantification of stearoyl-L-carnitine by GC- or LC-MS. Stearoyl-L-carnitine is a naturally occurring long-chain acylcarnitine.¹It inhibits sodium-dependent [³H]carnitine uptake in human proximal convoluted tubular (HPCT) cells by 52% when used at a concentration of 500 μM.²It also inhibits lecithin:cholesterol acyltransferase activity in rat, but not human, plasma when used at a concentration of 500 µM.³Plasma levels of stearoyl-L-carnitine are decreased in patients with chronic fatigue syndrome and increased in patients with end-stage renal disease.^4,1

1.Reuter, S.E., Evans, A.M., Faull, R.J., et al.Impact of haemodialysis on individual endogenous plasma acylcarnitine concentrations in end-stage renal diseaseAnn. Clin. Biochem.42(Pt 5)387-393(2005) 2.Huang, W., Shaikh, S.N., Ganapathy, M.E., et al.Carnitine transport and its inhibition by sulfonylureas in human kidney proximal tubular epithelial cellsBiochem. Pharmacol.58(8)1361-1370(1999) 3.Bell, F.P.Carnitine esters: Novel inhibitors of plasma lecithin: Cholesterol acyltransferase in experimental animals but not in man (Homo sapiens)Int. J. Biochem.15(2)133-136(1983) 4.Reuter, S.E., and Evans, A.M.Long-chain acylcarnitine deficiency in patients with chronic fatigue syndrome. Potential involvement of altered carnitine palmitoyltransferase-I activityJ. Intern. Med.270(1)76-84(2011)