PSNCBAM-1 是一种选择性 CB1 受体变构拮抗剂，EC50 为 0.1 μM。
货号:ajcx27004
CAS:877202-74-9
分子式:C22H21ClN4O
分子量：392.88
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CB1 receptor negative allosteric modulator (IC50 values are 45 and 209 nM for the inhibition of CP 55,940 and WIN 55,212-2 respectively). Has no effect at the CB2 receptor. Decreases food intake and body weight in rats.

Horswill et al (2007) PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats. Br.J.Pharmacol. 152 805 PMID:17592509 |German et al (2014) Diarylureas as allosteric modulators of the cannabinoid CB1 receptor: structure-activity relationship studies on 1-(4-chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1). J.Med.Chem. 57 7758 PMID:25162172