您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Urolithin C
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Urolithin C
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Urolithin C图片
规格:98%
分子量:244.2
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议

产品介绍
UrolithinC,是鞣花酸的多酚类肠道微生物代谢产物,是胰岛素分泌(insulinsecretion)的葡萄糖依赖性激活剂。UrolithinC是一种L型Ca2+通道开放剂,可增强Ca2+的流入。UrolithinC通过线粒体介导的途径诱导细胞凋亡(apoptosis),并刺激活性氧(ROS)的形成。
货号:ajcx29760
CAS:165393-06-6
分子式:C13H8O5
分子量:244.2
溶解度:DMSO: 125 mg/mL (511.88 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca2+ channel opener and enhances Ca2+ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation[1][2].

Urolithin C (20-100 μM; 1 hour; INS-1 cells) treatment enhances glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation in INS-1 β-cells[1].Urolithin C significantly inhibits the proliferation of PC12 cells. Urolithin C treatment actively increases the lactate dehydrogenase (LDH) release and lipid peroxidation malondialdehyde (MDA), stimulates reactive oxygen species (ROS) formation and mitochondrial membrane depolarization, and caused calcium dyshomeostasis[2].Urolithin C treatment induces apoptosis and S phase cell cycle arrest[2]. Western Blot Analysis[1] Cell Line: INS-1 cells

The pharmacokinetics of Urolithin C (10 mg/kg; intraperitoneal administration) in male Wistar rat (140-160 g) are studied. The half-life of the terminal part is 11.3 h and the total clearance (CL/F) is 3.41 L/h/kg. The initial volume of distribution (V1/F) and the steady-state volume of distribution (Vss/F) are 0.831 L/kg and 55.6 L/kg, respectively[3].

[1]. Slimane Toubal, et al. Urolithin C Increases Glucose-Induced ERK Activation Which Contributes to Insulin Secretion. Fundam Clin Pharmacol. 2020 Feb 21. [2]. Peipei Yin, et al. Urolithin C, a gut metabolite of ellagic acid, induces apoptosis in PC12 cells through a mitochondria-mediated pathway. RSC Advances. Issue 28, 2017. [3]. Morgane Bayle, et al. Development and Validation of a Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry Method for the Determination of Urolithin C in Rat Plasma and Its Application to a Pharmacokinetic Study. J Pharm Biomed Anal. 2016 Nov 30;131:33-39.