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GW311616 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GW311616 hydrochloride图片
CAS NO:197890-44-1
规格:98%
分子量:433.99
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
HNE inhibitor
CAS:197890-44-1
分子式:C19H32ClN3O4S
分子量:433.99
纯度:98%
存储:Store at -20°C

Background:

GW311616 hydrochloride is a potent, selective, intracellular, orally bioavailable and long duration inhibitor of human neutrophil elastase (HNE) with an IC50 value of 22nM [1].


GW311616 hydrochloride has been found to be selevtive over other human serine proteases with IC50 values of 22nM for HNE, >100μM for trypsin, cathepsin G, and plasmin, >3μM for chymotrypsin and tissue plasminogen activator. In HNE enzyme kinetic tests, GW311616 has been reported to inhibit HNE with a Ki value of 0.13nM. In addition, GW311616 has been revealed to inhibit HWB with an IC50 values of 0.67μM in HWB assay. Moreover, by measurement of intraneutrophil elastase activity, GW311616 hydrochloride has been suggested to have a dose-response and duration of action in blood samples of dog [1].


参考文献:
[1] Macdonald SJ1, Dowle MD, Harrison LA, Shah P, Johnson MR, Inglis GG, Clarke GD, Smith RA, Humphreys D, Molloy CR, Amour A, Dixon M, Murkitt G, Godward RE, Padfield T, Skarzynski T, Singh OM, Kumar KA, Fleetwood G, Hodgson ST, Hardy GW, Finch H. The discovery of a potent, intracellular, orally bioavailable,long duration inhibitor of human neutrophil elastase-GW311616A a development candidate. Bioorg Med Chem Lett. 2001 Apr 9;11(7):895-8.