MMP-3/MMP-12 Inhiibitor,highly selective
CAS：230961-21-4
分子式：C35H44N2O5
分子量：572.73
纯度：98%
存储：Store at -20°C

Background:

IC50: 23 nm (MMP-3)

Stromelysin-1 also known as matrix metalloproteinase-3 (MMP-3) is an enzyme that in humans is encoded by the MMP3 gene. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix and during tissue remodeling in normal physiological processes, such as embryonic development and reproduction, as well as in disease processes, such as arthritis, and tumour metastasis (http://en.wikipedia.org/wiki/MMP-3).

In vitro: UK-370106, a potent inhibitor of MMP-3 (IC50 ) 23 nM) with >1200-fold weaker potency vs MMP-1, -2, -9, and -14. MMP-13, may contribute to the pathology of chronic wounds. UK-370106 potently inhibited cleavage of [3H]-fibronectin by MMP-3 (IC50 ) 320 nM) but not cleavage of [3H]-gelatin by either MMP-2 or -9 (up to 100 íM). UK-370106 had little effect, at MMP-3 selective concentrations, on keratinocyte migration over a collagen matrix in vitro, which is a model of the re-epithelialization process [1].

In vivo: Following iv (rat) or topical administration to dermal wounds (rabbit), UK-370106 was cleared rapidly (t1/2=23 min) from plasma, but slowly (t1/2