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4-(6-Bromo-2-benzothiazolyl)benzenamine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
4-(6-Bromo-2-benzothiazolyl)benzenamine图片
CAS NO:566169-97-9
规格:98%
分子量:305.19
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
4-(6-Bromo-2-benzothiazolyl)benzenamine是β-淀粉样蛋白(β-amyloid)的PET(正电子发射断层扫描)示踪剂,可用于诊断神经疾病,如阿尔茨海默病和唐氏综合征。
CAS:566169-97-9
分子式:C13H9BrN2S
分子量:305.19
纯度:98%
存储:Store at -20°C

Background:

4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET (positron emission tomography) tracer that can be used in the diagnosis of neurological diseases, such as Alzheimer’s and Down’s syndrome.


4-(6-Bromo-2-benzothiazolyl)benzenamine (compound 6l) plus ultraviolet A (UVA) can induce caspase-3 activity, poly(ADP-ribose)polymerase cleavage, M30 positive CytoDeath staining, and subsequent apoptotic cell death. Treatment of A375 cells with 4-(6-Bromo-2-benzothiazolyl)benzenamine plus UVA results in a decrease in mitochondrial membrane potential (δΨmt), oxidative phosphorylation system (OXPHOS) subunits, and adenosine triphosphate (ATP) but an increase in mitochondrial DNA 4977-bp deletion via reactive oxygen species (ROS) generation. Transmission electron microscopy (TEM) observations also show major ultrastructural alterations of mitochondria[2].


4-(6-Bromo-2-benzothiazolyl)benzenamine plus UVA is shown to reduce murine melanoma size in a mouse model. 4-(6-Bromo-2-benzothiazolyl)benzenamine-PDT may serve as a potential ancillary modality for the treatment of melanoma[2].


[1]. Klunk W, et al. Benzothiazole derivative compounds, compositions and uses. WO2004083195 A1 [2]. Chen YK, et al. Apoptosis induced by 2-aryl benzothiazoles-mediated photodynamic therapy in melanomas via mitochondrial dysfunction. Chem Res Toxicol. 2014 Jul 21;27(7):1187-98.