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Esonarimod(KE-298)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Esonarimod(KE-298)图片
CAS NO:101973-77-7
规格:98%
分子量:280.34
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
Esonarimod是一种抗风湿药物。
CAS:101973-77-7
分子式:C14H16O4S
分子量:280.34
纯度:98%
存储:Store at -20°C

Background:

Esonarimod is an antirheumatic drug.


Esonarimod (KE-298) (10 to 300 μg/mL) suppresses the production of NO by RAW264.7 cells in a dose dependent manner. The IC50 of Esonarimod is 117.5 μg/mL. Esonarimod does not affect cellular viability at these tested doses. Esonarimod has no direct effect on NOS activity in cell-free extracts of RAW264.7 cells[1].


After repeated oral administration of Esonarimod (14C-KE-298), the radioactivity decreases rapidly and no tendency towards accumulation is found[2].


[1]. Inoue T, et al. KE-298 and its active metabolite KE-758 suppress nitric oxide production by murine macrophage cells and peritoneal cells from rats with adjuvant induced arthritis. J Rheumatol. 2001 Jun;28(6):1229-37. [2]. Hasegawa M, et al. Formation of a disulfide protein conjugate of the SH-group-containing metabolite (M-I) ofesonarimod (KE-298) and its elimination in rats. J Pharm Pharmacol. 2002 Apr;54(4):493-8.