PRN694 is a highly selective and potent covalent inhibitor of Tec kinases IL-2-inducible T cell kinase (ITK) and resting lymphocyte kinase (RLK). It inhibits Th1 and Th17 differentiation and cytokine production. References: Fuhriman JM, Winge MCG, Haberstock-Debic H, Funk JO, Bradshaw JM, Marinkovich MP. ITK and RLK inhibitor PRN694 improves skin disease in two mouse models of psoriasis. J Invest Dermatol. 2017 Nov 9. pii: S0022-202X(17)33145-7. doi: 10.1016/j.jid.2017.10.029. [Epub ahead of print] PubMed PMID: 29129599.

纯度：≥98%

CAS：1575818-46-0