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HQL 79
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
HQL 79图片
CAS NO:162641-16-9
规格:98%
分子量:377.48
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor
CAS:162641-16-9
分子式:C22H27N5O
分子量:377.48
纯度:98%
存储:Store at -20°C

Background:

HQL-79 is a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD2, and acts as an anti-allergic agent, with a Kd of 0.8 μM and an IC50 of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS[1].


HQL-79 is a competitive inhibitor against substrate PGH2 and a non-competitive one against GSH[1].


参考文献:
[1]. Aritake K, et al. Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J Biol Chem. 2006 Jun 2;281(22):15277-86. Epub 2006 Mar 17.