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Dihydrodaidzein
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dihydrodaidzein图片
CAS NO:17238-05-0
规格:98%
分子量:256.3
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议

产品介绍
estrogen receptor agonist
CAS:17238-05-0
分子式:C15H12O4
分子量:256.3
纯度:98%
存储:Store at -20°C

Background:

Dihydrodaidzein, an active, estrogenic metabolite of daidzein in colonic bacteria, probably is further metabolized to various bioactive compounds including equol. As an estrogen receptor agonist, dihydrodaidzein, at micromolar concentrations, activates the estrogen receptor-dependent growth of breast cancer cells. Daidzein, an isoflavonoid phytoestrogenic compound, is found in soybeans, clover, kudzu, and other legumes.


In vitro: Prostatic fluid and plasma concentrations of dihydrodaidzein were sufficient to block the growth of benign human prostatic epithelial cells (PrEC). Dihydrodaidzein showed a significant inhibitory effect on the growth of prostate cancer cell line LNCaP. Additionally, dihydrodaidzein slightly triggered the apoptosis of PrEC. In addition to affecting apoptosis, dihydrodaidzein decreased proliferation, which was associated with the changes in cell cycle distribution and Caspase 3 activation [1].


In vivo: Male C57B1/6 wild type mice were administered orally with dihydrodaidzein at a dose of 25 mg/kg/day for 4 weeks. Compared to the control groups, the neointima of mice treated with dihydrodaidzein was thickened. In dihydrodaidzein-treated mice, the intimal thickness in the non-injured right iliac artery was not altered. Moreover, neointimal proliferation was selectively blocked by dihydrodaidzein via suppressing the migration and proliferation of vascular smooth muscle cell and dampening the endothelial apoptosis [2].


参考文献:
[1].  Hedlund, T., Bokhoven, A., Johannes, W., Nordeen, S., & Ogden, L. Prostatic fluid concentrations of isoflavonoids in soy consumers are sufficient to inhibit growth of benign and malignant prostatic epithelial cells in vitro. The Prostate. 2006; 66(5): 557-566.
[2].  Shen, J., White, M., Husband, A., Hambly, B., & Bao, S. Phytoestrogen derivatives differentially inhibit arterial neointimal proliferation in a mouse model. European Journal of Pharmacology. 2006; 548(1-3): 123-128.