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MM-102
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MM-102图片
CAS NO:1417329-24-8
规格:98%
分子量:669.8
包装与价格:
包装价格(元)
2mg电议
5mg电议
20mg电议

产品介绍
MLL1 inhibitor,high-affinity peptidomimetic
CAS:1417329-24-8
分子式:C35H49F2N7O4
分子量:669.8
纯度:98%
存储:Store at -20°C

Background:

MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].


Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase. The interaction of MLL1 and WDR5 is essential for MLL1 enzymatic activity and is a target for the treatment of acute leukemia. MM-102 is a peptidomimetic of MLL1. It has a high binding affinity to WDR5 with IC50 value of 2.4nM [1].


MM-102 is reported to reduce the expression of MLL1 targeted genes HoxA9 and Meis-1 in MLL1-AF9 transduced murine cells. Since these two genes are required for MLL1 mediated leukemogenesis, MM-102 is found to inhibit cell growth of leukemia cells harboring MLL1 fusion proteins. It dose-dependently inhibits the cell growth in the MV4;11 and KOPN8 cell lines with IC50 values both of 25μM[1].


参考文献:
[1] Karatas H, Townsend EC, Cao F, Chen Y, Bernard D, Liu L, Lei M, Dou Y, Wang S. High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J Am Chem Soc. 2013 Jan 16;135(2):669-82.