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AIM-100
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AIM-100图片
CAS NO:873305-35-2
规格:98%
分子量:371.43
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
500mg电议
1g电议

产品介绍
Ack1 inhibitor
CAS:873305-35-2
分子式:C23H21N3O2
分子量:371.43
纯度:98%
存储:Store at -20°C

Background:

AIM-100 is a small inhibitor of Ack1 tyrosine kinase with IC50 value of 24 nM [1].


AIM-100 mimicked ATP and inhibited the activity of Ack1 significantly and specifically. It showed no inhibition activity for the other 30 kinases including PI3-kinase and AKT, and showed a five-fold higher IC50 value for Lck. In MEF cells treated with EGF, AIM-100 caused a remarkable decrease of the activation of Ack1. In the human prostate cancer cells LNCaP and LAPC4, AIM-100 treatment resulted in an increase of G0/G1 cell phase and subsequent cell growth suppression. These effects of AIM-100 also exerted in the pancreatic cancer cells. AIM-100 induced apoptosis in Panc-1 cells at concentration of 10 μM. Moreover, AIM-100 inhibited cell growth with GI50 values of 7 to 8 μM in CD-18, Panc-1, OV90, MCF-7 and MDA-MB-468 cancer cells [1, 2].


参考文献:
1. Mahajan K, Challa S, Coppola D, et al. Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity. The Prostate, 2010, 70(12): 1274-1285.
2. Mahajan K, Coppola D, Chen Y, et al. Ack1 tyrosine kinase activation correlates with pancreatic cancer progression. The American journal of pathology, 2012, 180(4): 1386-1393.