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TX-1918
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TX-1918图片
CAS NO:503473-32-3
规格:98%
分子量:228.2
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
TX-1918 is a cell-permeable tyrphostin derivative that inhibits eukaryotic elongation factor-2 kinase (eEF-2K; IC50 = 440 nM).
CAS:503473-32-3
分子式:C14H12O3
分子量:228.2
纯度:98%
存储:Store at -20°C

Background:

TX-1918 is a cell-permeable tyrphostin derivative that inhibits eukaryotic elongation factor-2 kinase (eEF-2K; IC50 = 440 nM). It inhibits Src, PKA, PKC, and EGFR kinases at much higher concentrations (IC50s = 4.4, 44, 44, and 440 uM, respectively). TX-1918 disrupts the proliferation of HepG2 and HCT116 tumor cells (EC50s = 2.07 and 230 uM, respectively) with >=5,000-fold and >=90-fold reduced mitochondrial- and hepato-toxicity, respectively when compared with the tyrphostin AG-17 [1]


Reference:
[1]. Hori, H., Nagasawa, H., Ishibashi, M., et al. TX-1123: An antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity. Bioor. Med. Chem. Lett. 10(10), 3257-3265 (2002).