CAS NO: | 872993-05-0 |
包装: | 10ug |
规格: | 98% |
市场价: | 2380元 |
分子量: | 376.5 |
Background:
Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.[1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.[2] Resolvin D1 (RvD1) is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.[1] A 17(R)-epimer of RvD1 can also be generated in aspirin-treated samples.[3] Both RvD1 and its 17(R)-configuration reduce human polymorphonuclear leukocyte (PMNL) transendothelial migration, the earliest event in acute inflammation, with EC50 values of