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HUHS015
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
HUHS015图片
CAS NO:1453097-13-6
规格:98%
分子量:318.37
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
HUHS015在体内体外都是PCA-1/ALKBH3强有力的抑制剂,持续的注射HUHS015能够显著的抑制DU145细胞的生长。
CAS:1453097-13-6
分子式:C19H18N4O
分子量:318.37
纯度:98%
存储:Store at -20°C

Background:

HUHS015 is a potent PCA-1/ALKBH3 inhibitor both in vitro and in vivo. The bioavailability (BA) of HUHS015 was 7.2% in rats after oral administration. Continuously administering HUHS015 significantly suppressed the growth of DU145 cells, which are human hormone-independent prostate cancer cells, in a mouse xenograft model without untoward effects. [1]




[1]. Nakao S et al. Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs. Bioorg Med Chem Lett, 2014 Feb 15, 24(4):1071-4.