Heraclenin，是一种天然呋喃香豆素，可从 Prangos pabularia 根部分离出来。Heraclenin 通过靶向激活的 T 细胞核因子 (NFAT) 来抑制人原代 T 细胞中 T 细胞受体介导的增殖，这种作用存在浓度依赖性。
CAS：2880-49-1
分子式：C16H14O5
分子量：286.28
纯度：98%
存储：Store at -20°C

Background:

Heraclenin, a natural furanocoumarin, isolated from the root parts of the plant Prangos pabularia. Heraclenin significantly inhibits T cell receptor-mediated proliferation in human primary T cells in a concentration-dependent manner by targeting nuclear factor of activated T-cells (NFAT)[1]. NFAT[1]

[1]. MÁrquez N, et al. Imperatorin inhibits T-cell proliferation by targeting the transcription factor NFAT. Planta Med. 2004 Nov;70(11):1016-21.