PHT-7.3 是一种选择性的 Ras 激酶抑制因子连接增强蛋白 1 (Cnk1) PH 结构域的抑制剂，抑制突变型 KRas，但不抑制野生型 KRas 癌细胞和肿瘤的生长和信号传导。
CAS：1614225-93-2
分子式：C24H23N3O3S
分子量：433.52
纯度：98%
存储：Store at -20°C

Background:

PHT-7.3 is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain, which inhibits mut-KRas, but not wild-type KRas cancer cell and tumor growth and signaling[1]. Cnk1 PH-domain[1]

[1]. Indarte M ，et al. An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors. Cancer Res. 2019 Jun 15;79(12):3100-3111.