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Eltrombopag
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Eltrombopag图片
CAS NO:496775-61-2
规格:98%
分子量:442.47
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
nonpeptide agonist of the thrombopoietin receptor
CAS:496775-61-2
分子式:C25H22N4O4
分子量:442.47
纯度:98%
存储:Store at -20°C

Background:

Eltrombopag (SB-497115) is a thrombopoietin (TPO) receptor agonist developed for certain conditions that lead to thrombocytopenia.


参考文献:
[1]. Erickson-Miller CL, et al. Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist. Stem Cells. 2009 Feb;27(2):424-30.
[2]. Erickson-Miller CL, et al. Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist. Exp Hematol. 2005 Jan;33(1):85-93.
[3]. McHutchison JG, et al. Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C. N Engl J Med. 2007 Nov 29;357(22):2227-36.
[4]. Jenkins JM, et al. Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist. Blood. 2007 Jun 1;109(11):4739-41.
[5]. Saleh MN, et al. Safety and efficacy of eltrombopag for treatment of chronic immune thrombocytopenia: results of the long-term, open-label EXTEND study. Blood. 2013 Jan 17;121(3):537-45.