Background:

5-Aminovaleric acid has been identified as an important five-carbon platform chemical, which can be used for the synthesis of polymers and other chemicals of industrial interest as well.

In vitro: 5-Aminovaleric acid, a GABA analog, was reported to be able to inhibit GABA uptake, inactivate GABA aminotransferase, and could also both agonize and antagonize GABAb receptors. In addition, 5-aminovaleric acid has been found to be able to increase glutamine concentrations, thus possibly compensating for the decreased concentration of brain glutamine [1].

In vivo: Animal study found that 5-aminovaleric acid-treated rats showed a 3.5-fold reduction in the number of seizures than PBS-treated rats. In addition, both groups showed similar seizure frequency (