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4E1RCat
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
4E1RCat图片
CAS NO:328998-25-0
规格:98%
分子量:478.45
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction
CAS:328998-25-0
分子式:C28H18N2O6
分子量:478.45
纯度:98%
存储:Store at -20°C

Background:

4E1RCat is a dual inhibitor of eIF4E:4E-BP1 and eIF4E:eIF4G interaction, and inhibits the binding of eIF4G to eIF4E with IC50 of 3.2 μM.
The complexity of eIF4A, eIF4E and eIF4G together forms the eIF4F, the eukaryotic initiation factor, which stimulates the loading of ribosomes onto mRNA templates in protein synthesis. The inhibition of this cap-dependent translation is associated with cancer initiation and progression [1].
4E1RCat prevents assembly of the eIF4F complex and inhibits cap-dependent translation [1]. 4E1RCat significantly inhibited 5′-cap-mediated mCherry synthesis while had little effect on the IRES-mediated DIAPH1-HA synthesis, which confirmed the specific inhibitory effect of 4E1RCat on 5′-cap-mediated translation [2].
参考文献:
[1]. Cencic R, Hall DR, Robert F, et al. Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F. Proc Natl Acad Sci, 2011, 108(3): 1046-1051.
[2]. Liao G, Liu G. Immediate translation of Formin DIAPH1 mRNA after its exiting the nucleus is required for its perinuclear localization in fibroblasts. PLoS One, 2013, 8(6): e68190.