Mal-PEG2-Val-Cit-PAB-OH is an peptide PEG Linker that may be used in antibody drug conjugation (ADC). The Val-Cit group is specifically cleaved by cathepsin B. Because this enzyme is only present in the lysosome, the ADC payload will be released only within the cell. The hydrophilic PEG spacer increases solubility in aqueous media. References: Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc400050k. Epub 2013 May 3. PubMed PMID: 23600922; PubMed Central PMCID: PMC3674550.

纯度：≥98%

CAS：2055041-38-6