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17β-hydroxy Exemestane
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
17β-hydroxy Exemestane图片
CAS NO:122370-91-6
规格:98%
分子量:298.4
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
17β-hydroxy Exemestane is the primary active metabolite of exemestane.
CAS:122370-91-6
分子式:C20H26O2
分子量:298.4
纯度:98%
存储:Store at -20°C

Background:

17β-hydroxy Exemestane is the primary active metabolite of exemestane . It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11. 17β-hydroxy Exemestane is an aromatase inhibitor (IC50 = 69 nM using human placental microsomes) and an androgen receptor (AR) agonist (IC50 = 39.6 nM) that is selective for AR over estrogen receptor α (ERα; IC50 = 21.2 μM). It stimulates growth of AR- and ERα-positive MCF-7 (EC50 = 2.7 μM) and T47D breast cancer cells (EC50s = 0.43 and 1,500 nM for AR- and ER-mediated growth, respectively) and inhibits proliferation of testosterone-treated aromatase-overexpressing MCF-7aro cells in a concentration-dependent manner. 17β-hydroxy Exemestane (20 mg/kg) inhibits increases in serum cholesterol and LDL levels and prevents decreases in bone mineral density in the lumbar vertebrae and femur, as well as femoral bending strength and compressive strength of the fifth lumbar vertebrae, in ovariectomized rats.