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thio-Miltefosine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
thio-Miltefosine图片
CAS NO:943022-11-5
规格:98%
分子量:423.6
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
thio-Miltefosine is a sulfur-containing derivative of miltefosine.
CAS:943022-11-5
分子式:C21H46NO3PS
分子量:423.6
纯度:98%
存储:Store at -20°C

Background:

thio-Miltefosine is a sulfur-containing derivative of miltefosine. Miltefosine is an inhibitor of phosphocholine cytidylyl transferase (CTP) and has antimetastatic properties. At concentrations of 3 and 25 µM, miltefosine inhibits proliferation of HaCaT cells (immortalized human keratinocyte cell line) by 50% and 94%, respectively. The mechanism of action of miltefosine is not well established, but the antiproliferative effect may be mediated by an increase in cellular ceramide which results in apoptosis. Treatment of cells with 25 µM miltefosine results in a 53% increase in ceramide concentration relative to control. Miltefosine is more than 90% effective in eradicating visceral infections of Leishmania species (kala azar), although the mechanism of this antiprotozoal activity is also poorly understood. The pharmacology of thio-miltefosine has not been published.