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Setmelanotide(RM-493)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Setmelanotide(RM-493)图片
CAS NO:920014-72-8
规格:98%
分子量:1117.31
包装与价格:
包装价格(元)
1mg电议
5mg电议
50mg电议
100mg电议

产品介绍
Setmelanotide(RM-493;BIM-22493;IRC-022493)是一种黑皮质素4受体(MC4R)激动剂,对人类MC4R的EC50值为0.27nM。
CAS:920014-72-8
分子式:C49H68N18O9S2
分子量:1117.31
纯度:98%
存储:Store at -20°C

Background:

Setmelanotide (RM-493;BIM-22493;IRC-022493) is a melanocortin 4 receptor (MC4R) agonist with an EC50 of 0.27 nM for human MC4R.


Melanocortin receptor agonists act in the brain to regulate food intake and body weight and, independently of these actions, affect insulin sensitivity. Setmelanotide exhibits agonist activity to human and rat MC4R with Kis of 2.1 and 2.7 nM and EC50s of 0.27 and 0.28 nM, respectively[1].


Inhibition of refeeding after an overnight fast by BIM-22493 is dependent on functional MC4R, and does not require MC3R. BIM-22493 acutely improves glucose homeostasis. Lepob/Lepob mice treated with BIM-22493 exhibits significantly improved glucose clearance when compared to controls. Chronic BIM-22493 treatment was associated with significantly lower levels of serum insulin, glucose and HOMA-IR values, suggesting an improvement in insulin sensitivity[1]. Treatment with setmelanotide results in transient decreases in food intake (35%), with persistent weight loss over 8 weeks of treatment (13.5%) in a diet-induced obese nonhuman primate model[2].


[1]. Kumar KG, et al. Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. Peptides. 2009 Oct;30(10):1892-900. [2]. Kievit P, et al. Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces insulin resistance, and improves cardiovascular function in diet-induced obese rhesus macaques. Diabetes. 2013 Feb;62(2):490-7.