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N-563
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N-563图片
CAS NO:140686-92-6
规格:98%
分子量:359.42
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
N-563是一种脱氧精胍菌素的模拟物,它可以刺激免疫应答,能够增强老鼠对白色念球菌的抵抗作用。
CAS:140686-92-6
分子式:C15H29N5O5
分子量:359.42
纯度:98%
存储:Store at -20°C

Background:

N-563 is an analogue of deoxyspergualin with an immunostimulating activity,it promotes resistance to Candida albicans infection in mice. In vivo: The protective effect of the N-563 against C. albicans infection was investigated in normal and immunosuppressed mice. In normal mice, N-563 treatment at 10 mg/kg for 3 days prior to infection significantly prolonged the survival time. In immunosuppressed mice treated with a single dose of cyclophosphamide 4 days prior to infection, N-563 at 3 and 10 mg/kg for 3 days prior to infection also significantly prolonged the survival time of mice. In addition, it augmented the phagocytic activity of neutrophils and enhanced the delayed type hypersensitivity reaction against C. albicans. Coincidentally, N-563 appeared to protect against secondary infection with C. albicans in the delayed type hypersensitivity-positive mice.[1]N-563 was dissolved in physiological saline and filtered through a Millipore filter (0.22μm).[1]




[1]. Aoyagi K. et al.The novel immunostimulant N-563, an analogue of deoxyspergualin, promotes resistance to Candida albicans infection in mice.The Journal of Antibiotics.Oct;47(10):1077-83.doi:10.7164/antibiotics.47.1077(1994)