LY178002是一种有效的5-lipoxygenase，phospholipaseA2抑制剂，对5-lipoxygenase的IC50值为0.6μM，能够抑制人多形核白细胞产生LTB4，同时可相对较弱地抑制cyclooxygenase的活性。
CAS：107889-32-7
分子式：C18H25NO2S
分子量：319.46
纯度：98%
存储：Store at -20°C

Background:

LY 178002 is a potent inhibitor of 5-lipoxygenase, phospholipase A2, with IC50 of 0.6 μM for 5-1ipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition on cyclooxygenase.

LY178002 inhibits the generation of LTB4, PLA2 and FCO with IC50s of 0.1, 6.3 and 4.2 μM [1].

LY 178002 (50 mg/kg) inhibits soft tissue swelling in the uninjected paw by 81%, and inhibits bone damage in rats. The minimum effective dose for LY178002 is 10 mg/kg p.o. In the established FCA model LY178002 at 50 mg/kg p.o. inhibits the uninjected paw swelling by 75%[1].

[1]. Panetta JA, et al. The anti-inflammatory effects of LY178002 and LY256548. Agents Actions. 1989 Jun;27(3-4):300-2.