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4E2RCat
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
4E2RCat图片
CAS NO:432499-63-3
规格:98%
分子量:455.93
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
4E2RCat是eIF4E-eIF4G相互作用的抑制剂,IC50值为13.5μM。
CAS:432499-63-3
分子式:C22H14ClNO4S2
分子量:455.93
纯度:98%
存储:Store at -20°C

Background:

4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM.


4E2RCat prevents the interaction between eIF4E (the cap-binding protein) and eIF4G (a large scaffolding protein), inhibiting cap-dependent translation. It significantly decreases human coronavirus 229E (HCoV-229E) replication, reducing the percentage of infected cells and intra- and extracellular infectious virus titers. 4E2RCat inhibits cap-dependent translation in a dose-dependent manner. 4E2RCat inhibits cap-dependent FF translation but not EMCV IRES-driven Ren translation. 4E2RCat inhibits coronavirus replication in a dose- and time-dependent manner[1].


4E2RCat inhibits protein synthesis in vivo and it is not a consequence of increased cell death[1].


[1]. Cencic R, et al. Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication. J Virol. 2011 Jul;85(13):6381-9.