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PSB-12062(N-(p-Methylphenylsulfonyl)phenoxazine)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PSB-12062(N-(p-Methylphenylsulfonyl)phenoxazine)图片
CAS NO:55476-47-6
规格:98%
分子量:337.39
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
PSB-12062是有效,选择性的P2X4拮抗剂,对人类P2X4的IC50值为1.38μM。
CAS:55476-47-6
分子式:C19H15NO3S
分子量:337.39
纯度:98%
存储:Store at -20°C

Background:

PSB-12062 is a potent and selective P2X4 antagonist with an IC50 of 1.38 μM for human P2X4.


PSB-12062 shows similar potency in human, rat, and mouse species. PSB-12062 shows to be allosteric in nature with a 35-fold selectivity toward P2X4 versus P2X1, P2X2, P2X3, and P2X7. However, PSB-12062 is unable to completely block ATP-induced P2X4-mediated calcium influx even when used at high concentrations (>30 μM)[1].



[1]. Hernandez-Olmos V, et al. N-substituted phenoxazine and acridone derivatives: structure-activity relationships of potent P2X4 receptor antagonists. J Med Chem. 2012 Nov 26;55(22):9576-88. [2]. Stokes L, et al. P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology.Front Pharmacol. 2017 May 23;8:291.